![]() It currently includes 306 B cell repertoires collected from 121 human individuals, including healthy, vaccinated, and autoimmune disease donors. cAb-RepĬAb-Rep is a database of curated antibody repertoires. OAS now contains both unpaired and paired antibody sequences. These repertoires cover diverse immune states, organisms (primarily human and mouse), and individuals. It currently contains over one billion sequences, from more than 79 different studies. OAS is a project to collect and annotate immune repertoires for use in large-scale analysis. AAAAA is quite useful for users to check antibody sequences for plausibility to find out about unusual residues, sequencing mistakes, frameshifts, insertions, and deletions. All sequences of variable domain germline and rearranged sequences in AAAAA are numbered in an identical way. ![]() AHo’s Amazing Atlas of Antibody AnatomyĪAAAA is a tool for antibody structural analysis, modeling, and engineering. Therapeutic Structural Antibody Database (Thera-SAbDab) tracks all antibody- and nanobody-related therapeutics recognized by the World Health Organisation (WHO), and identifies any corresponding structures in the SAbDab with near-exact or exact variable domain sequence matches. The user can select structures, according to these attributes as well as structural properties such as complementarity determining region loop conformation and variable domain orientation. Structural Antibody Database (SAbDab) is a database containing all the antibody structures available in the PDB, annotated and presented in a consistent fashion. Check out their tutorial to learn How to obtain an antibody sequence, Step-by-step. Each antibody is assigned a unique ID number that can be used in academic publications to increase the reproducibility of experiments. Launched in 2020, the ABCD Database is a repository of sequenced antibodies, integrating curated information about the antibody and its antigen with cross-links to standardized databases of chemical and protein entities. The ABCD (for AntiBodies Chemically Defined) database to enter one’s own sequences for analysis.to analyze trends across sequences in the database, and.to search the database to find information about sequences (and structures) including detailed annotations, identification of unusual residues, post-translational modification sites, etc.,.abYsisĪbYsis is a web-based antibody research system that includes an integrated database of antibody sequence and structure data. ![]() For example, IMGT/mAb-DB, the monoclonal antibody (mAb) database of IMGT, provides an expert resource on mAbs with clinical indications, and on fusion proteins for immune applications (FPIA). IMGT comprises seven databases encompassing antibody sequence, genome, and structure. The international ImMunoGeneTics information system (IMGT) is a global, high-quality integrated knowledge resource specializing in immunoglobulins (Ig), T cell Receptors (TcR), and Major Histocompatibility Complex (MHC) molecules of human and other vertebrates. UniProt does not specifically focus on antibodies as such, it only includes a representative set of germline antibody sequences and a limited number of non-germline antibody sequences. ![]() UniProt is a comprehensive, high-quality, and freely accessible resource of protein sequence and functional information. However, when the sequence is available, there are numerous antibody sequence databases that can be used by researchers for the purpose of sequence search. Sometimes, some genomes have not been sequenced, and this requires the use of de novo protein sequencing to elucidate the sequence. However, other databases containing sequences from immunoglobulin genes or sequenced antibody proteins offer much more insight for the purposes of antibody engineering and characterization. These types of antibody databases are often used for reproducibility purposes. There are a number of online antibody databases storing different types of information such as suppliers, usage data, and publication references. For antibody reagent users, knowing the sequences allows them to perform sequence analysis/alignment to identify binding and cross-reactivity so they can conduct rational experimental design. Antibody sequences are critical for antibody engineering and protein characterization in therapeutic development.
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